Uzee Brown, Jr. is a published composer and arranger, having written the musical prologue for Spike Lee's School Daze. In 1992 he was nominated for the Audelco award in Black theater as outstanding musical director and arranger of the off-Broadway musical play Zion. Zion was presented at Theater in the Square as a venue of the 1996 Centennial Olympics in Atlanta, Georgia.

Brown is a respected researcher and lecturer on African-American vocal music. His arrangements and compositions are published with Lawson-Gould Publishing Company of New York and Roger Dean Publishing Company.

Dr. Brown is former chair of the Department of Music at Clark Atlanta University, Professor of Music at Morehouse College, President of the National Association of Negro Musicians and co-founder and chairman of the Board of Directors of Onyx Opera Atlanta, a non-profit operatic ensemble founded in 1988 with the purpose of performing works by African-American composers as well as western European operatic repertoire. He was elected to the Board of Trustees at Morehouse College. His engagements include masterclasses, workshops, and recitals of African-American music from work songs and spirituals to art songs. Dr. Brown's church music activities have included choral director and Director of Music appointments at Mt. Calvary Baptist Church, Cascade United Methodist Church, Ben Hill United Methodist Church and director of the Church Choir at Ebenezer Baptist Church.